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Take a cartridge from its box, and then remove its white plastic cover. Place the cartridge in mouthpiece with the open end facing the atomiser.
If you take a look inside the cartridge, you will see a wet piece of polyester wool, which is where the nicotine solution is stored. (Polyester wool is used in fish tank filters, so if you need more you can buy some at a pet shop).
Now screw the atomiser back onto the battery, and make sure you screw it all the way but do not use excessive force. Take care not to damage the threads (If you feel much resistance as you begin to screw the atomiser on then unscrew and start again)